The Transposon Registry

Displaying 301 - 320 of 2083

Tn5541

Characteristics

Tn5541 is a 4.7-kb transposon found in Fremyella diplosiphon UTEX 481 strain Fd33. It contains two ORFs: tnpA (transposase) and orf1 (protein with unknown function).

References

Schaefer, M. R. and K. Kahn (1998). "Cyanobacterial Transposons Tn5469 and Tn5541 Represent a Novel Noncomposite Transposon Family." J Bacteriol 180(22): 6059-6063. PMCID: PMC107686

Accession number

AF072896

Tn5542

Metabolism
Benzene Catabolism

Characteristics

Tn5542 is an 11.9-kb composite transposon found on plasmid pHMT112 in Pseudomonas putida ML2. It contains genes for benzene catabolism (bedC1C2BAD), which are flanked by IS1489v1 and IS1489v2 elements.

References

Fong, K. P. Y., et al. (2000). "The Genes for Benzene Catabolism in Pseudomonas putida ML2 Are Flanked by Two Copies of the Insertion Element IS1489, Forming a Class-I-Type Catabolic Transposon, Tn5542." Plasmid 43(2): 103-110. DOI: 10.1006/plas.1999.1442

Accession number

AF148496

Tn5561

Characteristics

Tn5561 is found in Rhodococcus erythropolis SQ1, which contains IS1415, istB gene (encoding helper protein), orf2, orf3 and orf4.

References

Nagy, I., et al. (1997). "Transposition of the IS21-related element IS1415 in Rhodococcus erythropolis." J Bacteriol 179(14): 4635-4638. DOI: 10.1128/jb.179.14.4635-4638.1997

Accession number

AF002247

Tn5563

Efflux functions

Characteristics

Tn5563 is a 6.3-kb Tn-3 family transposon, found on plasmid pRA2 in Pseudomonas alcaligenes NCIB 9867 (strain P25X). It contains genes encoding transposase (TnpA), resolvase (TnpR), merT and merP (mercuric ion transport proteins).

References

Chieng, Y. C., et al. (1998). "Tn5563, a transposon encoding putative mercuric ion transport proteins located on plasmid pRA2 of Pseudomonas alcaligenes." FEMS Microbiology Letters 165(2): 253-260. DOI: 10.1111/j.1574-6968.1998.tb13154.x

Accession number

NC_005909

Tn5564

Antibiotic Resistance
Chloramphenicol

Characteristics

Tn5564 is a 4.2-kb transposon, found on R-plasmid pTP10 in Corynebacterium glutamicum. It contains IS1513, ORF1/cmx gene (conferring chloramphenicol resistance) and ORF2.

References

Tauch, A., et al. (1998). "Corynebacterium striatum Chloramphenicol Resistance Transposon Tn5564:Genetic Organization and Transposition in Corynebacterium glutamicum." Plasmid 40(2): 126-139. DOI: 10.1006/plas.1998.1362

Accession number

AF024666

Tn5565

Virulence Determinants
Toxin production

Characteristics

Tn5565 is a 6.3-kb composite transposon-like structure, which found in Clostridium perfringens. It contains IS1469 and enterotoxin gene (cpe), which are flanked by IS1470 elements.

References

Brynestad, S. and P. E. Granum (1999). "Evidence that Tn5565, which includes the enterotoxin gene in Clostridium perfringens, can have a circular form which may be a transposition intermediate." FEMS Microbiology Letters 170(1): 281-286. DOI: 10.1111/j.1574-6968.1999.tb13385.x

Tn5613

Characteristics

Tn5613 is a 3.5-kb composite transposon, found in Acinetobacter sp. strain ADP1. It contains two IS1236 elements, flanking orf1, encoding protein with unknown function.

References

Segura A, Bünz PV, D’Argenio DA, Ornston LN. Genetic Analysis of a Chromosomal Region Containing vanA and vanB, Genes Required for Conversion of Either Ferulate or Vanillate to Protocatechuate in Acinetobacter. Journal of Bacteriology. 1999;181(11):3494-3504. PMCID: PMC93818

Accession number

AF091240

Tn5706

Antibiotic Resistance
Tetracycline

Characteristics

Tn5706 is a 4.4-kb transposon, found in Pasteurella multocida. It contains tet(H)-tetR resistance gene, which were flanked by two IS1592 elements.

References

Kehrenberg C, Werckenthin C, Schwarz S. Tn5706, a Transposon-Like Element from Pasteurella multocida Mediating Tetracycline Resistance. Antimicrobial Agents and Chemotherapy. 1998;42(8):2116-2118. PMCID: PMC105878

Accession number

Y15510

Tn5707

Metabolism
Chlorocatechol degradation

Characteristics

Tn5707 is a 15-kb composite transposon, which was found on plasmid pENH91 in Alcaligenes eutrophus (Ralstonia eutropha) NH9, isolated in Japan. It contains chlorocatechol-degradative genes, cbnR-ABCD, encoding chlorocatechol 1,2-dioxygenase, chloromuconate cycloisomerase, dienelactone hydrolase and maleylacetate reductase, respectively. The cbnR-ABCD was flanked by two IS1600 elements.

References

Ogawa N, Miyashita K. The Chlorocatechol-Catabolic Transposon Tn5707 of Alcaligenes eutrophus NH9, Carrying a Gene Cluster Highly Homologous to That in the 1,2,4-Trichlorobenzene-Degrading Bacterium Pseudomonas sp. Strain P51, Confers the Ability To Grow on 3-Chlorobenzoate. Applied and Environmental Microbiology. 1999;65(2):724-731. PMCID: PMC91086

Accession number

Tn5718

Heavy Metal Resistance
Mercury Resistance

Characteristics

Tn5717 is a 10-kb Tn5053 family transposon, which was found on plasmid pSB102, isolated from a microbial population residing in the rhizosphere of alfalfa. It contains 14 putative ORFs in which nine of them were mercury resistance genes (merRTPGCABDE) and the other five were genes involving in Tn5718 transposition.

References

Schneiker S, Keller M, Dröge M, Lanka E, Pühler A, Selbitschka W. The genetic organization and evolution of the broad host range mercury resistance plasmid pSB102 isolated from a microbial population residing in the rhizosphere of alfalfa. Nucleic Acids Research. 2001;29(24):5169-5181. DOI: 10.1093/nar/29.24.5169

Accession number

AJ304453

Tn5719

Heavy Metal Resistance
Chromate resistance

Characteristics

Tn5719 is an 8.4-kb Tn501-family transposon, which was found on plasmid pB4, isolated from a microbial community growing in activated sludge. It contains seven ORFs: tnpA and tnpR (transposase and resolvase for the transposition) and chrBAC (conferring chromate resistance).

References

Tauch, A., et al. (2003). "The 79,370-bp conjugative plasmid pB4 consists of an IncP-1β backbone loaded with a chromate resistance transposon, the strA-strB streptomycin resistance gene pair, the oxacillinase gene bla NPS-1, and a tripartite antibiotic efflux system of the resistance-nodulation-division family." Molecular Genetics and Genomics 268(5): 570-584. DOI: 10.1007/s00438-002-0785-z

Accession number

AJ431260

Tn5721

Virulence Determinants
Bacteriocin production

Characteristics

Tn5721 is a 11.5-kb composite transposon, found on plasmid pES2 in Lactococcus lactis subsp. lactis strain C2102. It contains two IS1675 elements flanking lacticin 481 (bacteriocin) operon (lctAMTFEG).

References

Dufour A, Rincé A, Uguen P, Le Pennec J-P. IS1675, a Novel Lactococcal Insertion Element, Forms a Transposon-Like Structure Including the Lacticin 481 Lantibiotic Operon. Journal of Bacteriology. 2000;182(19):5600-5605. DOI: 10.1128/JB.182.19.5600-5605.2000

Accession number

U91581

Tn5801

Antibiotic Resistance
Tetracycline

Characteristics

Tn5801 is a 25.8-kb transposon, which was first found in Staphylococcus aureus Mu50 strain. It is related to Tn916, which contains many ORFs similar to those of Tn916, including tetracycline resistance gene tet(M) (97.7% DNA similarity to Tn916 tet(M)) and an integrase gene (different fromxisTn916/intTn916 from Tn916) .

References

Kuroda, M., et al. (2001). "Whole genome sequencing of meticillin-resistant Staphylococcus aureus." The Lancet 357(9264): 1225-1240. DOI: 10.1016/S0140-6736(00)04403-2

De Vries LE, Hasman H, Jurado Rabadán S, Agersø Y. Sequence-Based Characterization of Tn5801-Like Genomic Islands in Tetracycline-Resistant Staphylococcus pseudintermedius and Other Gram-positive Bacteria from Humans and Animals. Frontiers in Microbiology. 2016;7:576. DOI: 10.3389/fmicb.2016.00576

Accession number

BA000017

Tn6000

Dr Adam Roberts

UCL Eastman Dental Institute

Antibiotic Resistance
Tetracycline

Characteristics

Previously designated EfcTn1, this conjugative transposon confers tetracycline resistance via tet(S). It is based on a Tn916-like backbone however the integrase is more related to the integrase of Staphylococcal pathogenicity islands.

References

Roberts et al.,(2006) Characterization of the Ends and Target Site of a Novel Tetracycline Resistance-Encoding Conjugative Transposon from Enterococcus faecium 664.1H1. Journal of Bacteriology 188:4356-61. doi: 10.1128/JB.00129-06

Brouwer et al., (2010) Characterisation of the conjugative transposon Tn6000 from Enterococcus casseliflavis 664.1H1 (formerly Enterococcus faecium 664.1H1). FEMS Microbiology Letters. 309(1):71-6. doi: 10.1111/j.1574-6968.2010.02018.x

Novais C, et al., (2012) Different genetic supports for the tet(S) gene in Enterococci. Antimicrob Agents Chemother. 56(11):6014-8. doi: 10.1128/AAC.00758-12.

Novais C, et al., (2012) A tet(S/M) hybrid from CTn6000 and CTn916 recombination. Microbiology. 158(Pt 11):2710-1. doi: 10.1099/mic.0.062729-0.

Starikova I et al., (2013) Fitness costs of various mobile genetic elements in Enterococcus faecium and Enterococcus faecalis. J Antimicrob Chemother. 2013 Dec;68(12):2755-65. doi: 10.1093/jac/dkt270

Ciric L, et al., (2014) Minocycline resistance in an oral Streptococcus infantis isolate is encoded by tet(S) on a novel small, low copy number plasmid. FEMS Microbiol Lett. 2014 Apr;353(2):106-15. doi: 10.1111/1574-6968.12410

Accession number

FN555436

Contact

adam.roberts@lstmed.ac.uk

Tn6001

Dr Sung-Pin Tseng

NTU CLS&MB Institute

Antibiotic Resistance
Carbapenem
Fosfomycin
Gentamicin
Kanamycin
Sulphonamide

Characteristics

Tn6001 is a 12.1-kb transposon-like element found in a multidrug-resistant Pseudomonas aeruginosa clinical isolate in Taiwan. It contained tnpA and tnpR (similar to Tn1403), an integron In450 [containing integron integrase, six gene cassettes (blaVIM-3, orf2 (putative fosfomycin resistance protein), three aacA4 and aadB), sul1 gene in the 3'CS]. orfB, orfC,orfD and truncated orfA, similar to Tn1403 and Tn1404, were also found as part of this transposon.

References

Tseng SP et al.,(2007) Tn6001, a Transposon-Like Element Containing the blaVIM-3-harboring Integron In450. Antimicrobial Agents and Chemotherapy. 51(11):4187-90. doi: 10.1128/AAC.00542-07

Sung-Pin Tseng, Jui-Chang Tsai, Lee-Jene Teng, Po-Ren Hsueh (2009) Dissemination of transposon Tn6001 in carbapenem-non-susceptible and extensively drug-resistant Pseudomonas aeruginosa in Taiwan. J Antimicrob Chemother. 2009 Dec; 64(6): 1170–1174. doi: 10.1093/jac/dkp341

Accession number

EF138817

Contact

b86404032@ntu.edu.tw

Tn6002

Dr Philip Warburton

UCL Eastman Dental Institute

Antibiotic Resistance
Erythromycin
Tetracycline

Characteristics

Tn6002 is a 20.9-kb Tn916-like element, found in Streptococcus cristatus. It had a 2.8-kb erythromycin resistance gene encoding inserted within orf20.

References

Warburton PJ et al.,(2007) Demonstration of in vivo transfer of doxycycline resistance mediated by a novel transposon. Journal of Antimicrobial Chemotherapy. 60(5):973-80 DOI: 10.1093/jac/dkm331

Accession number

AY898750

Contact

p.warburton@eastman.ucl.ac.uk

Tn6003

Prof Maria Pia Montanari

Institute of Microbiology and Biomedical

Antibiotic Resistance
Erythromycin
Kanamycin
Streptothricin
Tetracycline

Characteristics

Tn6003 is a 25.1-kb Tn6002-like element with the insertion of MAS element (4.2 kb: contains an erm(B) (lacking the stop codon) with its peptide leader; an aminoglycoside-streptothricin resistance cluster (aadE-sat4-aphA-3 genes) (100% homology, save for a deletion of 511 nucletides in aadE); and an ORF identical to orf47 of plasmid pRE25 of E. faecalis).

References

Cochetti et al.,(2007) New Tn916-related elements causing erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci. Journal of Antimicrobial Chemotherapy. 60(1):127-31 DOI: 10.1093/jac/dkm120

Accession number

AM410044

Contact

mp.montanari@univpm.it

Tn6004

Dr Elisabetta Mantengoli

Università degli studi di siena

Antibiotic Resistance
Cefotaxime
Ciprofloxacin
Gentamicin
Tobramycin
Ceftazidime

Characteristics

Tn3-like transposon containing an IS26 insertion in tnpR, blaTEM-92 and tnpA genes.

References

Endimiani A et al., (2007). Spread in an Italian Hospital of a clonal Acinetobacter baumannii Strain Producing the TEM-92 Extended-Spectrum Beta-Lactamase. Antimicrobial Agents and Chemotherapy. 51(6):2211-2214. DOI: 10.1128/AAC.01139-06

Contact

mantengoli@unisi.it

Tn6005

Dr Maurizio Labbate

Macquaarie University

Antispetic Resistance
Heavy Metal Resistance
Mercury Resistance

Characteristics

Tn6005 is a 23.7-kb transposon, found in Enterobacter cloacae strain JKB7. It composed of Tn6006 (containing qacE2b gene), which inserted into the res site of Tn5036/Tn3926 (containing mercury resistance gene cluster: merEDACPTR).

References

Labbate M, Chowdhury PR, Stokes HW. A Class 1 Integron Present in a Human Commensal Has a Hybrid Transposition Module Compared to Tn402: Evidence of Interaction with Mobile DNA from Natural Environments. Journal of Bacteriology. 2008;190(15):5318-5327. DOI: 10.1128/JB.00199-08

Accession number

EU591509

Contact

mlabbate@bio.mq.edu.au

Tn6006

Dr Maurizio Labbate

Macquaarie University

Antispetic Resistance

Characteristics

Tn6006 is a 15.7-kb transposon, composing of two transposons: Tn6007 (class 1 integron with qacE2b gene) and Tn6008. It was found in Enterobacter cloacae strain JKB7, which was shown to be inserted into a Tn5036/Tn3926 transposon.

References

Accession number

EU591509

Contact

mlabbate@bio.mq.edu.au

The Transposon Registry

Pages