The Transposon Registry

Displaying 501 - 520 of 2138
Tn6187
Dr Benoit Doublet
INRA
  • Antibiotic Resistance
  • Carbapenem
  • Chloramphenicol
  • Gentamicin
  • Kanamycin
  • Sulphonamide
  • Heavy Metal Resistance
  • Mercury Resistance
Characteristics
Tn6187 is a 32.6-kb transposon, found in plasmid pR55 from Klebsiella pneumoniae. It contained two mercury resistance operons and two transposition modules that are related to Tn21 and Tn1696, respectively, and an In0-type integron [containing two gene cassettes (aadB and blaOXA-21), sul1 in 3'CS and IS1326]. Three IS5075 elements and catA1 gene were also found on this transposon.
References

Doublet et al, 2012. Complete nucleotide sequence of the multidrug resistance IncA/C plasmid pR55 from Klebsiella pneumoniae isolated in 1969. Journal of Antimicrobial Chemotherapy. 67: 2354-60. DOI: 10.1093/jac/dks251

Accession number
Contact
benoit.doublet@tours.inra.fr
Tn6188
Dr Stephan Schmitz-Esser
Institute for Milk Hygine, VetMed Vienna
  • Antispetic Resistance
  • Quaternary ammonium compound
Characteristics
Tn6188 is a 5.1-kb Tn554-like transposon, found in Listeria monocytogenes strain 6179, 4423, and K15. It encoded three consecutive transposase genes (tnpABC), one Quaternary ammonium compound-resistance protein QacH, and a putative tetR family transcriptional regulator.
References

Müller A, Rychli K, Muhterem-Uyar M, et al. Tn6188 - A Novel Transposon in Listeria monocytogenes Responsible for Tolerance to Benzalkonium Chloride. Chang Y-F, ed. PLoS ONE. 2013;8(10):e76835. DOI: 10.1371/journal.pone.0076835.

Accession number
Contact
stephan.schmitz-esser@vetmeduni.ac.at
Tn6189
Dr Katie Solomon
University College Dublin
Contact
katie.solomon@ucd.ie
Tn6190
Mr Michael Brouwer
UCL Eastman Dental Institute
  • Antibiotic Resistance
  • Tetracycline
Characteristics
Tn6190 is a 17.9-kb Tn916-like conjugative transposon, found in Clostridium difficile strain M120. It contained homologues to all Tn916 ORFs [including tet(M)], except orf12.
References

Corver, J., et al. (2012). "Analysis of a Clostridium difficile PCR ribotype 078 100 kilobase island reveals the presence of a novel transposon, Tn6164." BMC Microbiology 12(1): 130. DOI: 10.1186/1471-2180-12-130

Accession number
Contact
m.brouwer@ucl.ac.uk
Tn6191
Dr Zhiyong Zong
West China Hospital
  • Antibiotic Resistance
  • Methicillin
Characteristics
Tn6191 is a 6.3-kb composite transposon found in Staphylococcus haemolyticus clinical isolate strain WCH1. It contained two IS431 elements, flanking 4 genes [mecA, orf19, maoC (putative acyl dehydratase) and orf21].
References

Zong Z. Characterization of a complex context containing mecA but lacking genes encoding cassette chromosome recombinases in Staphylococcus haemolyticus. BMC Microbiology. 2013;13:64. DOI: 10.1186/1471-2180-13-64.

Accession number
Contact
zongzhiy@scu.edu.cn
Tn6192
Dr Miao He
Wellcome Trust Sanger Institute
  • Efflux functions
Characteristics
Tn6192 is a 37.5-kb CTn5-like element, found in Clostridium difficile 027/BI/NAP1 in FQR1 and FQR2 lineages. It contained 21 ORFs (CDR20291_1789-CDR20291_1809), which encoded ABC transporter proteins, two-component system and proteins for conjugation.
References

He M, Miyajima F, Roberts P, et al. Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nature genetics. 2013;45(1):109-113. DOI: 10.1038/ng.2478.

Accession number
Contact
mh10@sanger.ac.uk
Tn6193
Dr Miao He
Wellcome Trust Sanger Institute
Contact
mh10@sanger.ac.uk
Tn6194
Dr Miao He
Wellcome Trust Sanger Institute
  • Antibiotic Resistance
  • Erythromycin
  • Tetracycline
Characteristics
Tn6194 (also called CTnCD11) is a 28-kb Tn916-like family conjugative transposon, found in Clostridium difficile strain R20291. It carried erm(B) and genes encoding tyrosine integrases and recombinases.
References

He M, Sebaihia M, Lawley TD, et al. Evolutionary dynamics of Clostridium difficile over short and long time scales. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(16):7527-7532. DOI: 10.1073/pnas.0914322107.

Accession number
Contact
mh10@sanger.ac.uk
Tn6195
Miss Yang Liu
China Agricultural University
Contact
lysonna@yahoo.cn
Tn6196
Prof Yang Wang
China Agricultural University
Characteristics
Tn6196 is a 3.6-kb transposon, found in plasmid pEC2-NDM-3 from Escherichia coli strain EC2. It contained tnpA and tnpR genes.
References

Wailan AM, Sidjabat HE, Yam WK, et al. Mechanisms Involved in Acquisition of blaNDM Genes by IncA/C2 and IncFIIY Plasmids. Antimicrobial Agents and Chemotherapy. 2016;60(7):4082-4088. DOI: 10.1128/AAC.00368-16.

Accession number
Contact
vetwangyang@yahoo.cn
Tn6197
Prof Yang Wang
China Agricultural University
Contact
vetwangyang@yahoo.cn
Tn6198
Mr David Bertsch
ETH Z
  • Antibiotic Resistance
  • Tetracycline
  • Trimethoprim
Characteristics
Tn6198 is a 21.3-kb Tn916-family conjugative transposon from the clinical Listeria monocytogenes strain TTH-2007. It contained a 3.3-kb DNA fragment [carrying orfU2, orfU2 and dfrG genes] inserted in between orf23 and orf24 of Tn916. Apart from dfrG fragment, the sequences of Tn6198 and Tn916 share a similarity of > 99.9%.
References

Bertsch, D., et al. (2013). "Tn6198, a novel transposon containing the trimethoprim resistance gene dfrG embedded into a Tn916 element in Listeria monocytogenes." J Antimicrob Chemother 68(5): 986-991. DOI: 10.1093/jac/dks531

Accession number
Contact
david.bertsch@hest.ethz.ch
Tn6199
Mr Samuel Njoroge
KEMRI
Contact
samihnjoroge@gmail.com
Tn6200
Dr Lena Ciric
UCL Eastman Dental Institute
Contact
l.ciric@ucl.ac.uk
Tn6201
Dr Liangan Chen
General Hospital-Peoples Liberation Army
Contact
chenliangan301@163.com
Tn6202
Dr Michael Mulvey
Public Health Agency of Canada
  • Antibiotic Resistance
  • Vancomycin
Characteristics
Tn6202 is a 43.7-kb Enterococcus faecalis strain N00-410. It contained 42 ORFs, containing a conjugation region including a putative oriT (VE02–VE16), an excision/integration region (VE41 and VE42), a regulatory region (VE34 and V35) and accessory regions (VE17–VE33 and the vanE operon: vanE-XYE-TE-RE-SE).
References

Boyd, D. A. and M. R. Mulvey (2013). "The VanE operon in Enterococcus faecalis N00-410 is found on a putative integrative and conjugative element, Tn6202." J Antimicrob Chemother 68(2): 294-299. DOI: 10.1093/jac/dks394

Accession number
Contact
michael.mulvey@phac-aspc.gc.ca
Tn6203
Dr Yongfei Hu
IMCAS
  • Antibiotic Resistance
  • Ampicillin
  • Gentamicin
  • Kanamycin
  • Sulphonamide
  • Heavy Metal Resistance
  • Mercury Resistance
Characteristics
Tn6203 is a 17.5 kb Tn402-like class 1 integron/transposon, found in Achromobacter xylosoxidans strain X02736. Compared with its counterpart in the Salmonella genomic island SGI1, Tn6203 incorporates two new antibiotic resistance gene cassettes (aac(6')-IIa, aadB) on its class 1 integron, a mercury resistance Tn4378-like transposon (merEDAPTR) with a disruption of IS6100. blaPSE-1 and sul1 resistance genes were also found on the class 1 integron in its gene cassette and 3'CS.
References

Hu Y, Zhu Y, Ma Y, et al. Genomic Insights into Intrinsic and Acquired Drug Resistance Mechanisms in Achromobacter xylosoxidans. Antimicrobial Agents and Chemotherapy. 2015;59(2):1152-1161. DOI: 10.1128/AAC.04260-14.

Accession number
Contact
huyf@im.ac.cn
Tn6204
Ms Karla Pelegrino
Grupo Fleury
  • Antibiotic Resistance
  • Streptomycin
  • Heavy Metal Resistance
  • Mercury Resistance
Characteristics
Tn6204 is an 11.5-kb composite Tn510-like transposon and contains mercury resistance genes, an IS1071 and a Tn5393C modified transposon (containing streptomycin resistance genes: strA and strB). This transposon is part of the pBRA100 Incp1B plasmid, found in a strain of Mycobacterium abscessus subsp. bolletii resistant to glutaraldehyde disinfection.
References
Pelegrino,K.O., Sampaio,S.C.F., Mandeulbaum,K.L., Cerdeira,L.T., McCulloch,J.A. and Sampaio,J.L.M. (Unpublished) IncP-1 beta plasmids extend their host range to Mycobacterium abscessus subsp bolletii
Accession number
Contact
karla.pelegrino@grupofleury.com.br
Tn6205
Ms Karla Pelegrino
Grupo Fleury
  • Antibiotic Resistance
  • Streptomycin
Characteristics
Tn6205 is a 2.8-kb transposon, found on plasmid BRA100 from Mycobacterium abscessus subsp. bolletii F1725. It is part of Tn6204, which contains non-functional tnpA transposase (due to insertion of IS1071), truncated tnpR and strAB streptomycin resistance genes.
References
Pelegrino,K.O., Sampaio,S.C.F., Mandeulbaum,K.L., Cerdeira,L.T., McCulloch,J.A. and Sampaio,J.L.M. (Unpublished) IncP-1 beta plasmids extend their host range to Mycobacterium abscessus subsp bolletii
Accession number
Contact
karla.pelegrino@grupofleury.com.br
Tn6206
Dr Zhenyu Xuan
University of Texas at Dallas
  • Antibiotic Resistance
  • Carbapenem
Characteristics
Tn6206 is a 7.8-kb composite transposon found in Acinetobacter baumannii strain BJAB0715, BJAB0868 and BJAB07104. It contained two ISAba1 elements flanking 8 ORFs, which encoded blaOXA-23, two copies of ATPase and DEAD/H, YeeB, YeeC and a few hypothetical proteins.
References

Zhu L, Yan Z, Zhang Z, et al. Complete Genome Analysis of Three Acinetobacter baumannii Clinical Isolates in China for Insight into the Diversification of Drug Resistance Elements. Bereswill S, ed. PLoS ONE. 2013;8(6):e66584. DOI: 10.1371/journal.pone.0066584.

Accession number
Contact
zxx091000@utdallas.edu

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