The Transposon Registry

Displaying 681 - 700 of 2084
Tn6367
Prof Dongsheng Zhou
Beijing Institute of Microbiology and Ep
  • Antibiotic Resistance
  • Ampicillin
  • Efflux functions
Characteristics
Tn6367 is a 5.7-kb composite transposon, found on plasmid p20049-KPC in Klebsiella pneumoniae strain 20049. It contains two IS26 flanking truncated ISEcp1, blaCTX-M-65, IS903D, iroN (iron outer membrane transporter), truncated ncp (methyl-accepting chemotaxis protein).
References

Shi L, Feng J, Zhan Z, et al. Comparative analysis of blaKPC-2- and rmtB-carrying IncFII-family pKPC-LK30/pHN7A8 hybrid plasmids from Klebsiella pneumoniae CG258 strains disseminated among multiple Chinese hospitals. Infect Drug Resist. 2018;11:1783–1793. Published 2018 Oct 11. DOI: 10.2147/IDR.S171953

Accession number
Contact
zhouds@qq.com
Tn6368
Dr Ricaurte Alejandro Marquez-Ortiz
University of technology Sydney
Characteristics
Tn6368 is a 2.8-kb transposon, found on plasmid p06-1619-NDM in Providencia rettgeri strain 06-1619. It contain tnpA, tnpR and tnpM genes.
References

Marquez-Ortiz RA, Haggerty L, Olarte N, et al. Genomic Epidemiology of NDM-1-Encoding Plasmids in Latin American Clinical Isolates Reveals Insights into the Evolution of Multidrug Resistance. Genome Biol Evol. 2017;9(6):1725–1741. DOI: 10.1093/gbe/evx115

Accession number
Contact
alejandro.marquezortiz@uts.edu.au
Tn6369
Dr Ricaurte Alejandro Marquez-Ortiz
University of technology Sydney
  • Efflux functions
Characteristics
Tn6369 is a 9.2-kb transposon, found on plasmid pRB151-NDM in Providencia rettgeri strain RB151. It contains tnpA, tnpR and genes for adaptation processes (ions intake) [betP_4-usp-ychM_3-arsC_2].
References

Marquez-Ortiz RA, Haggerty L, Olarte N, et al. Genomic Epidemiology of NDM-1-Encoding Plasmids in Latin American Clinical Isolates Reveals Insights into the Evolution of Multidrug Resistance. Genome Biol Evol. 2017;9(6):1725–1741. DOI: 10.1093/gbe/evx115

Accession number
Contact
alejandro.marquezortiz@uts.edu.au
Tn6370
Prof Dongsheng Zhou
Beijing Institute of Microbiology and Ep
Contact
zhouds@qq.com
Tn6371
Ms Lara Almeida
University of São Paulo
Contact
larameal@gmail.com
Tn6372
Mr João Botelho
UCIBIO/REQUIMTE, Microbiology, FFUP
Contact
joaobotelho9@hotmail.com
Tn6373
Mr João Botelho
UCIBIO/REQUIMTE, Microbiology, FFUP
Contact
joaobotelho9@hotmail.com
Tn6374
University of Idaho
Characteristics
Tn6370 is found on plasmid in Shewanella oneidensis strain MR-1. It contains a putative toxin-antitoxin (TA) system of the family HEPN-MNT and a resolvase (TnpR).
References

Stalder T, Rogers LM, Renfrow C, Yano H, Smith Z, Top EM. Emerging patterns of plasmid-host coevolution that stabilize antibiotic resistance. Sci Rep. 2017;7(1):4853. Published 2017 Jul 7. DOI: 10.1038/s41598-017-04662-0

Tn6375
Prof Dongsheng Zhou
Beijing Institute of Microbiology and Epidemiology
  • Antibiotic Resistance
  • Cephalosporins
  • Gentamicin
Characteristics
Tn6375 is an 18.8-kb transposon, found on plasmid p447-IMP in Klebsiella pneumoniae strain 447. It was derived from the Tn3-family unit transposon Tn1722 with an IRL–tnpAR–res–mcp (methyl-accepting chemotaxis protein)–IRR structure and it had undergone two major evolutionary events: (i) the insertion of In73 at a site within res, resulting in its truncation from 120 bp to 99 bp; and (ii) the integration of ISEcp1:IS1R–blaCTX-M-14–IS903D (at a site within mcp, splitting it into two separate parts), in which an intact IS1R element was inserted into ISEcp1 (interrupting tnpAISEcp1 into two separate parts).
References

Zhe Zhan, Lingfei Hu, Xiaoyuan Jiang, Lijun Zeng, Jiao Feng, Weili Wu, Weijun Chen, Huiying Yang, Wenhui Yang, Bo Gao, Zhe Yin, Dongsheng Zhou, Plasmid and chromosomal integration of four novel blaIMP-carrying transposons from Pseudomonas aeruginosa, Klebsiella pneumoniae and an Enterobacter sp., Journal of Antimicrobial Chemotherapy, Volume 73, Issue 11, November 2018, Pages 3005–3015, DOI: 10.1093/jac/dky288

Accession number
Contact
dongshengzhou1977@gmail.com
Tn6376
Prof Dongsheng Zhou
Beijing Institute of Microbiology and Epidemiology
Characteristics
Tn6376 is a 4.9-kb transposon, found on plasmid pP10159-3 in Citrobacter freundii strain P10159. It contains tnpA, tnpR and ISKpn17.
References

Li B, Feng J, Zhan Z, et al. Dissemination of KPC-2-Encoding IncX6 Plasmids Among Multiple Enterobacteriaceae Species in a Single Chinese Hospital. Front Microbiol. 2018;9:478. Published 2018 Mar 19. DOI: 10.3389/fmicb.2018.00478

Accession number
Contact
dongshengzhou1977@gmail.com
Tn6377
Prof Dongsheng Zhou
Beijing Institute of Microbiology and Epidemiology
  • Antibiotic Resistance
  • Cephalosporins
Characteristics
Tn6377 is a 4-kb transposon, found on plasmid p675920-1 in Klebsiella pneumoniae strain 675920. It was generated from insertion of the ISEcp1–blaCTX-M-65–IS903D unit at a site within the methyl-accepting chemotaxis gene mcp of the Tn3-family unit transposon Tn1722.
Accession number
Contact
dongshengzhou1977@gmail.com
Tn6378
Prof Dongsheng Zhou
Beijing Institute of Microbiology and Epidemiology
  • Antibiotic Resistance
  • Azithromycin
  • Cephalosporins
  • Gentamicin
Characteristics
Tn6378 was derived from Tn1696 after four major evolutionary events: (i) interruption of IRR into two parts by IS5075; (ii) loss of mer; (iii) insertion of In73 [IRi–intI1–blaIMP-8–aacA4′-3–tniABQR–IRt] at the same position within res, truncating it into a single 83 bp remnant; and (iv) insertion of the macAB–tolC region (ABC-type macrolide-resistance efflux system) downstream of In73.
References

Zhe Zhan, Lingfei Hu, Xiaoyuan Jiang, Lijun Zeng, Jiao Feng, Weili Wu, Weijun Chen, Huiying Yang, Wenhui Yang, Bo Gao, Zhe Yin, Dongsheng Zhou, Plasmid and chromosomal integration of four novel blaIMP-carrying transposons from Pseudomonas aeruginosa, Klebsiella pneumoniae and an Enterobacter sp., Journal of Antimicrobial Chemotherapy, Volume 73, Issue 11, November 2018, Pages 3005–3015, DOI: 10.1093/jac/dky288

Accession number
Contact
dongshengzhou1977@gmail.com
Tn6379
Prof Dongsheng Zhou
Beijing Institute of Microbiology and Epidemiology
Contact
dongshengzhou1977@gmail.com
Tn6380
Prof Dongsheng Zhou
Beijing Institute of Microbiology and Epidemiology
Contact
dongshengzhou1977@gmail.com
Tn6381
Prof Dongsheng Zhou
Beijing Institute of Microbiology and Epidemiology
  • Heavy Metal Resistance
  • Arsenate resistance
Characteristics
Tn6381 is a 22.8-kb transposon, found on plasmid pA324-IMP in Klebsiella pneumoniae strain A324. It was a derivative of Tn6535 (tnpA–res–tnpR and arsenic-resistance (ars) unit) with an insertion of a Tn3-family unit transposon Tn6399b [IS1816-truncated tnpA-res-tnpR-fgh-glo-adh-fmr] at a site within arsB.
References

Liang Q, Jiang X, Hu L, et al. Sequencing and Genomic Diversity Analysis of IncHI5 Plasmids. Front Microbiol. 2019;9:3318. Published 2019 Jan 14. DOI: 10.3389/fmicb.2018.03318

Accession number
Contact
dongshengzhou1977@gmail.com
Tn6382
Prof Dongsheng Zhou
Beijing Institute of Microbiology and Epidemiology
  • Antibiotic Resistance
  • Ampicillin
  • Carbapenem
  • Cephalosporins
  • Kanamycin
  • Antispetic Resistance
  • Quaternary ammonium compound
  • Heavy Metal Resistance
  • Mercury Resistance
Characteristics
Tn6382 is a 20.4-kb transposon, found on plasmid pA324-IMP in Klebsiella pneumoniae strain A324. It contains IS5075, truncated Tn1696 backbone [tnpA-tnpR-res--mercury resistance operon (merACPTR)] with an insertion of In1376 [blaIMP-38-qacG2-aacA4] and partial Tn6339 [IS1X2, blaCTX-M-3-blaTEM-1B-tnpR-res-tnpA].
References

Liang Q, Jiang X, Hu L, et al. Sequencing and Genomic Diversity Analysis of IncHI5 Plasmids. Front Microbiol. 2019;9:3318. Published 2019 Jan 14. DOI: 10.3389/fmicb.2018.03318

Accession number
Contact
dongshengzhou1977@gmail.com
Tn6383
Prof Dongsheng Zhou
Beijing Institute of Microbiology and Epidemiology
  • Antibiotic Resistance
  • Azithromycin
  • Carbapenem
  • Chloramphenicol
  • Kanamycin
  • Sulphonamide
  • Tunicamycin
  • Antispetic Resistance
  • Quaternary ammonium compound
  • Heavy Metal Resistance
  • Arsenate resistance
  • Mercury Resistance
Characteristics
Tn6383 is a 48.7-kb transposon found on plasmid p12208-IMP in Klebsiella pneumoniae strain 12208. It contains IS5075, Tn1696 backbone [tnpA,tnpR,urf2Y, mercury resistance operon (merEDACPTR)] and In823p12208-IMP [blaIMP-4-qacED-sul1 integron, Truncated Tn1548 (ISCR1, armA, msr(E)-mph(E) macrolide resistance genes and IS26), Tn6535 remnant (arsenate resistance operon), IS26-catA2-IS26 unit, ISKax2, aacC2-tmrB region, IS10R, IS10L and IS6100].
References

Liang Q, Jiang X, Hu L, et al. Sequencing and Genomic Diversity Analysis of IncHI5 Plasmids. Front Microbiol. 2019;9:3318. Published 2019 Jan 14. DOI: 10.3389/fmicb.2018.03318

Accession number
Contact
dongshengzhou1977@gmail.com
Tn6384
Prof Dongsheng Zhou
Beijing Institute of Microbiology and Epidemiology
  • Antibiotic Resistance
  • Chloramphenicol
  • Fluoroquinolone
  • Kanamycin
  • Rifampicin
  • Spectinomycin
  • Streptomycin
  • Sulphonamide
  • Antispetic Resistance
  • Quaternary ammonium compound
  • Heavy Metal Resistance
  • Mercury Resistance
Characteristics
Tn6384 is a 26-kb transposon, found on plasmid p13190-VIM in Klebsiella pneumoniae strain 13190. It contains IS5075, Tn1696 backbone [tnpA-tnpR-urf2-mercury resistance operon (merEDACPTR)], In916 (blaVIM-1-aacA4-aphA15-aadA1b-catB2-qacED1), IS26-catA2-IS26 unit, and In37 (aacA4cr-blaOXA-1-catB2-arr3-qacED1-sul1, IS6100).
References

Liang Q, Jiang X, Hu L, et al. Sequencing and Genomic Diversity Analysis of IncHI5 Plasmids. Front Microbiol. 2019;9:3318. Published 2019 Jan 14. DOI: 10.3389/fmicb.2018.03318

Accession number
Contact
dongshengzhou1977@gmail.com
Tn6385
Nanyang Technical University
Tn6386
Mr João Botelho
University of Porto
Contact
joaobotelho9@hotmail.com

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