The Transposon Registry

Displaying 761 - 780 of 2138

Tn6450

Chang-Wei Lei

Antibiotic Resistance
Ampicillin
Azithromycin
Cephalosporins
Florfenicol
Hygromycin
Kanamycin
Lincomycin
Neomycin
Quinalone
Rifampicin
Sulphonamide
Trimethoprim

Characteristics

Tn6450 is a 65.8-kb transposon, found in Proteus mirabilis strain SNYG17. It contains Tn7 remnant (tnsABC and truncated tnsD), truncated mcp of Tn1721, two class 1 integrons: In5-type [aac(6′)-Ib-cr and arr-3 cassettes and two copies of the 3′-CS separated by ISCR1 and a region containing blaDHA-1 and ampR genes] and Tn21 class 1 integron [dfrA12 and aadA2 cassettes and resistance gene qnrA1 linked to ISCR1], Tn4352B [IS26-aphA-IS26], mphE-msrE-IS26, Tn21 (tnpA21-tnpR-tnpM), a 20,849-bp region (containing floR, sul2, hph, and aacC4 resistance genes) and a hybrid integron (a nonfunctional intI2 and 3′-CS of class 1 integron carrying lunF, dfrA1, and aadA1 cassettes).

References

Chen YP, Lei CW, Kong LH, et al. Tn6450, a Novel Multidrug Resistance Transposon Characterized in a Proteus mirabilis Isolate from Chicken in China. Antimicrob Agents Chemother. 2018;62(4):e02192-17. Published 2018 Mar 27. DOI: 10.1128/AAC.02192-17

Accession number

MF805806

Contact

leichangwei@126.com

Tn6451

Chang-Wei Lei

Antibiotic Resistance
Carbapenem
Chloramphenicol
Clindamycin
Florfenicol
Kanamycin
Rifampicin
Spectinomycin
Streptomycin
Streptothricin
Trimethoprim

Characteristics

Tn6451 is a 111.2-kb transposon, found in Morganella morganii strain BCMM24. It contains Tn7 (tnsABCDE and three gene cassettes (aadA1, sat2 and dfrA1), truncated Tn3 transposon (harbours multiple different mobile genetic elements (complete or truncated) and 12 resistance genes, 7 of which were carried by a novel class 1 integron with five gene cassettes, aac(6′)-Ib-cr, blaOXA-1, catB3, arr-3 and dfrA27) and a cfr-containing segment (IS26-cfr-ΔTn554 tnpB-ΔTn3 family tnpA-IS26). Diverse mobile genetic elements including eight intact ISs (three copies of IS26, an ISEc59, an ISVsa5, an ISEc68, an ISSpu20 and an IS5D)

References

Yanpeng Chen, Changwei Lei, Lei Zuo, Linghan Kong, Zhuangzhuang Kang, Jinxin Zeng, Xiuzhong Zhang, Hongning Wang, A novel cfr-carrying Tn7 transposon derivative characterized in Morganella morganii of swine origin in China, Journal of Antimicrobial Chemotherapy, Volume 74, Issue 3, March 2019, Pages 603–606, DOI: 10.1093/jac/dky494

Accession number

MG832661

Contact

leichangwei@126.com

Tn6452

Dr. Jens Andre Hammerl

Antibiotic Resistance
Colistin

Characteristics

Tn6452 is transposon, found on plasmid pSE11-03671 from Salmonella enterica subsp. enterica serovar Typhimurium isolates. It contains mcr-5 colistin resistance gene.

References

Borowiak, M., et al. (2019). "Characterization of mcr-5-harboring Salmonella enterica subsp. enterica serovar Typhimurium isolates from animal and food origin in Germany." Antimicrob Agents Chemother. DOI: 10.1128/AAC.00063-19

Accession number

MK360094

Contact

jens-andre.hammerl@bfr.bund.de

Tn6453

Xing-Ping Li

Contact

pingzi0622@163.com

Tn6454

Professor Javier Escobar-Perez

Contact

escobarjavier@unbosque.edu.co

Tn6455

Li Daixi

Contact

lidaixi_dy@163.com

Tn6456

Dr Alida Veloo

University Medical Center Groningen

Antibiotic Resistance
Metronidazole
Efflux functions

Characteristics

Tn6456 is a 7.8-kb transposon, found in Prevotella bivia strain 3721. It contains nimK metronidazole resistance gene, qacE small drug efflux pump and IS1380, together with genes integrase and a mobilization protein.

References

Veloo ACM, Chlebowicz M, Winter HLJ, Bathoorn D, Rossen JWA. Three metronidazole-resistant Prevotella bivia strains harbour a mobile element, encoding a novel nim gene, nimK, and an efflux small MDR transporter. J Antimicrob Chemother. 2018;73(10):2687–2690. DOI: 10.1093/jac/dky236

Accession number