The Transposon Registry

Displaying 401 - 420 of 2084
Tn6087
Dr Lena Ciric
UCL Eastman Dental Institute
  • Antibiotic Resistance
  • Tetracycline
  • Antispetic Resistance
  • CTAB
Characteristics
Tn6087 is a 21.1-kb Tn916-like element isolated from Streptococcus oralis strain F.MI.5. It contained an insertion of qrg gene (encoding resistance to CTAB), flanked by two IS1216 elements, at orf15 of Tn916.
References

Ciric L, Mullany P, Roberts AP. Antibiotic and antiseptic resistance genes are linked on a novel mobile genetic element: Tn6087. Journal of Antimicrobial Chemotherapy. 2011;66(10):2235-2239. DOI: 10.1093/jac/dkr311.

Accession number
Contact
l.ciric@eastman.ucl.ac.uk
Tn6088
Dr Chyi-Liang Chen
Chang Gung Memorial Hospital, Linkou
  • Antibiotic Resistance
  • Ceftriaxone
  • Chloramphenicol
  • Kanamycin
  • Streptomycin
  • Sulphonamide
  • Tetracycline
  • Trimethoprim
  • Antispetic Resistance
  • Quaternary ammonium compound
  • Efflux functions
  • Heavy Metal Resistance
  • Mercury Resistance
Characteristics
Tn6088 is a 43.3-kb Tn21-like transposon, located at the region of 5,781-49,059 in plasmid pSC138 of Salmonella enterica serotype Choleraesuis. It contains a truncated mer operon [merADE], two In2-like integrons, two IS26, and four internal transposons (truncated Tn1721 [tetA-tetR], Tn6089 [cat2 gene], Tn6091 and Tn6092 [blaCMY-2 and sugE (multidrug efflux protein)]. In In2-like integrons, two sets of gene cassettes (sat-orf054-aadA2-cmlA-aadA1 and dhfr-orf031-aadA2) were found with the sul1, qacF and qacEΔ1 in the 3′-CS. These two integrons also carry two transposon-like structures: Tn4352B [kan gene] and Tn6090.
References

Ye, J., et al. (2011). "Analysis of pSC138, the multidrug resistance plasmid of Salmonella enterica serotype Choleraesuis SC-B67." Plasmid 65(2): 132-140. DOI: 10.1016/j.plasmid.2010.11.007

Accession number
Contact
dinoschen@adm.cgmh.org.tw
Tn6089
Dr Chyi-Liang Chen
Chang Gung Memorial Hospital, Linkou
  • Antibiotic Resistance
  • Chloramphenicol
Characteristics
Tn6089 is a 3-kb composite transposon, located at the region of 9,103-12,141 in plasmid pSC138 of Salmonella enterica serotype Choleraesuis. It is a putative transposon, contains two IS26 at both ends and a chloramphenicol-resistant gene, cat2.
References

Ye, J., et al. (2011). "Analysis of pSC138, the multidrug resistance plasmid of Salmonella enterica serotype Choleraesuis SC-B67." Plasmid 65(2): 132-140. DOI: 10.1016/j.plasmid.2010.11.007

 
Accession number
Contact
dinoschen@adm.cgmh.org.tw
Tn6090
Dr Chyi-Liang Chen
Chang Gung Memorial Hospital, Linkou
Characteristics
Tn6090 is a 6-kb putative composite transposon, located at the region of 29,322-35,243 in plasmid pSC138 of Salmonella enterica serotype Choleraesuis. It contained two IS26 at both ends, flanking two component-related genes (hisKA-mopB-rfaF-betR).
References

Ye, J., et al. (2011). "Analysis of pSC138, the multidrug resistance plasmid of Salmonella enterica serotype Choleraesuis SC-B67." Plasmid 65(2): 132-140. DOI: 10.1016/j.plasmid.2010.11.007

Accession number
Contact
dinoschen@adm.cgmh.org.tw
Tn6091
Dr Chyi-Liang Chen
Chang Gung Memorial Hospital, Linkou
Characteristics
Tn6091 is a 6.5-kb putative transposon, located at the region of 51,909-58,399 in plasmid pSC138 of Salmonella enterica serotype Choleraesuis. It contained two IS26 at both ends and a flock of conjugation-related genes, including traL, traM, traN, traO, traP, traQ.
References

Ye, J., et al. (2011). "Analysis of pSC138, the multidrug resistance plasmid of Salmonella enterica serotype Choleraesuis SC-B67." Plasmid 65(2): 132-140. DOI: 10.1016/j.plasmid.2010.11.007

Accession number
Contact
dinoschen@adm.cgmh.org.tw
Tn6092
Dr Chyi-Liang Chen
Chang Gung Memorial Hospital, Linkou
  • Antibiotic Resistance
  • Ceftriaxone
  • Efflux functions
Characteristics
Tn6092 is a 4.1-kb putative TnpA_ISEcp1-mediated transposon, located at the region of 68,273-72,369 in plasmid pSC138 of Salmonella enterica serotype Choleraesuis. It contained three drug-resistance genes, blaAmpC, blc, and sugE (multidrug efflux protein), and three inverted repeat sequences, IRL, IRR1, and IRR2, whereas two direct repeats were flanked by both of IRL and IRR2.
References

Ye, J., et al. (2011). "Analysis of pSC138, the multidrug resistance plasmid of Salmonella enterica serotype Choleraesuis SC-B67." Plasmid 65(2): 132-140. DOI: 10.1016/j.plasmid.2010.11.007

Accession number
Contact
dinoschen@adm.cgmh.org.tw
Tn6093
Dr Marco Maria D'Andrea
Università degli Studi di Siena
  • Antibiotic Resistance
  • Amoxicillin
  • Ampicillin
  • Aztreonam
  • Cefotaxime
  • Ceftazidime
  • Ceftriaxone
  • Antispetic Resistance
  • Quaternary ammonium compound
  • Efflux functions
Characteristics
Tn6093 is a 6.2-kb transposon, consisting of ISEcp1 and a fragment of the Citrobacter freundii-derived chromosomal DNA containing genes blaCMY-16, blc and sugE (multidrug efflux protein) and a part of the ColE1-type plasmid backbone (regions orf6, mobB and delta RNAII). blaCMY-16 is a gene encoding a C. freundii-like AmpC cephalosporinase variant conferring resistance to a majority of beta-lactam antibiotics. Tn6093 was originally identified in a Proteus mirabilis clinical isolate NO-051/03 from an Italian hospital.
References

D’Andrea MM, Nucleo E, Luzzaro F, et al. CMY-16, a Novel Acquired AmpC-Type β-Lactamase of the CMY/LAT Lineage in Multifocal Monophyletic Isolates of Proteus mirabilis from Northern Italy. Antimicrobial Agents and Chemotherapy. 2006;50(2):618-624. DOI: 10.1128/AAC.50.2.618-624.2006.

Accession number
Contact
marco.dandrea@uniroma2.it
Tn6094
Dr Mingoia Marina
Department of Biomedical Sciences
Contact
m.mingoia@univpm.it
Tn6095
Dr Hao-Yuan Lee
Chang Gung Memorial Hospital
Contact
d9700101@gmail.com
Tn6096
Dr Lukasz Dziewit
University of Warsaw
Contact
ldziewit@biol.uw.edu.pl
Tn6097
Dr Lukasz Dziewit
University of Warsaw
  • Antibiotic Resistance
  • Daunorubicin
  • Doxorubicin
  • Metabolism
  • Arginine deiminase
  • Nitrogen metabolism
Characteristics
Tn6097 is a 17.8-kb composite transposon, which was captured in Paracoccus ferrooxidans NCCB 1300066 by using the trap plasmid pCM132TC. It contained genes involved in arginine deiminase pathway (arcABCD genes), putative proteins in nitrogen metabolism (orf2-orf5) and daunorubicin-doxorubicin resistance (hlyD-drrA-drrB genes).
References

Dziewit L, Baj J, Szuplewska M, et al. Insights into the Transposable Mobilome of Paracoccus spp. (Alphaproteobacteria). Van Melderen L, ed. PLoS ONE. 2012;7(2):e32277. DOI: 10.1371/journal.pone.0032277.

Accession number
Contact
ldziewit@biol.uw.edu.pl
Tn6098
Prof Roland Siezen
NIZO food research
  • Efflux functions
  • Metabolism
  • Sucrose metabolism
  • α-galactoside metabolism
  • Virulence Determinants
  • Cold shock proteins
Characteristics
Tn6098 is a 51-kb transposon conjugative transposon found in Lactococcus lactis. It was predicted to contain 59 ORFs, encoding proteins for excision and integration of conjugative transposons (xis and int genes), tRNA-Met, sucrose phosphorylase [sucP], ABC transporter, metabolism of α-galactosides (typical plant oligosaccharides) [agaABCR], cold shock proteins [cspB2-C2-A2], Mg2+/Co2+ transporter, and an N5-(carboxyethyl)-ornithine synthase. Several IS elements were located on this transposon, including two IS1216 (flanking α-galactosides gene cluster), IS981 (flanking LLKF_2275).
References

Machielsen R, Siezen RJ, van Hijum SAFT, van Hylckama Vlieg JET. Molecular Description and Industrial Potential of Tn6098 Conjugative Transfer Conferring Alpha-Galactoside Metabolism in Lactococcus lactis  . Applied and Environmental Microbiology. 2011;77(2):555-563. DOI: 10.1128/AEM.02283-10.

Accession number
Contact
r.siezen@cmbi.ru.nl
Tn6099
Prof Gena Tribble
University of Texas Dental Branch
  • Antibiotic Resistance
  • Tetracycline
Characteristics
Tn6099 is a 7-kb transposon found in Prevotella nigrescens strain PDRC11. It contained 5 ORFs, including tetQ, rteA (putative signal transduction sensor), istA (putative transposase similar to IS21), istB (transposon helper protein; similar to IS21 IstB protein) and orfA.
References

Tribble GD, Garza JJ, Yeung VL, et al. Genetic Analysis of Mobile tetQElements in Oral Prevotella Species. Anaerobe. 2010;16(6):604-609. DOI: 10.1016/j.anaerobe.2010.08.008.

Accession number
Contact
gena.d.tribble@uth.tmc.edu
Tn6100
Prof Gena Tribble
University of Texas Dental Branch
  • Antibiotic Resistance
  • Tetracycline
Characteristics
Tn6099 is a 6.3-kb transposon found in Prevotella nigrescens strain PDRC22B. It was similar to Tn6099 (the first 5.7 kb), but the 1 kb region of secondary structure found in Tn6099 is absent from Tn6100, and instead a 308 bp region containing a 3′ continuation of the istB is present. It contained 4 ORFs, including tetQ, rteA (putative signal transduction sensor), istA (putative transposase similar to IS21), and istB (transposon helper protein; similar to IS21 IstB protein).
References

Tribble GD, Garza JJ, Yeung VL, et al. Genetic Analysis of Mobile tetQElements in Oral Prevotella Species. Anaerobe. 2010;16(6):604-609. DOI: 10.1016/j.anaerobe.2010.08.008.

Accession number
Contact
gena.d.tribble@uth.tmc.edu
Tn6101
Dr Helena Seth-Smith
Wellcome Trust Sanger Insitute
Characteristics
Tn6101 (also called ICE6101 and ICESe4) is an 84-kb ICE found in Salmonella Hadar strain 18. It contained genes encoding putative mobility functions (replication, type IVB pilus, transfer/conjugation, and integration/excision) and also genes involving in adhesion/uptake, 50S ribosomal protein, and restriction-modification system (type III).
References

Seth-Smith HMB, Fookes MC, Okoro CK, et al. Structure, Diversity, and Mobility of the Salmonella Pathogenicity Island 7 Family of Integrative and Conjugative Elements within Enterobacteriaceae. Journal of Bacteriology. 2012;194(6):1494-1504. DOI: 10.1128/JB.06403-11.

Accession number
Contact
hss@sanger.ac.uk
Tn6102
Ms Diya Sen
University of Idaho
Contact
diyasen@vandals.uidaho.edu
Tn6103
Mr Michael Brouwer
UCL Eastman Dental Institute
  • Efflux functions
Characteristics
Tn6103 (also called CTn027) is an 84.9-kb conjugative transposon found in Clostridium difficile strain R20291. It contained three transposons (each contain a recombinase gene): Tn6104 [21 ORFs: a putative transcriptional regulator (ORF 1747), a two-component regulatory system (ORFs 1748 and 1749), an ABC transporter (ORFs 1750, 1751 and 1752), three sigma factor-like proteins (ORFs 1754, 1755 and 1756), a putative toxin-antitoxin system (ORFs 1759 and 1760) and a phage-associated protein (ORF 1762)], Tn6105 [11 ORFs], and Tn6106 [11 ORFs].
References

Brouwer MSM, Warburton PJ, Roberts AP, Mullany P, Allan E. Genetic Organisation, Mobility and Predicted Functions of Genes on Integrated, Mobile Genetic Elements in Sequenced Strains of Clostridium difficile . Highlander SK, ed. PLoS ONE. 2011;6(8):e23014. DOI: 10.1371/journal.pone.0023014.

Accession number
Contact
m.brouwer@ucl.ac.uk
Tn6104
Mr Michael Brouwer
UCL Eastman Dental Institute
  • Efflux functions
Characteristics
Tn6104 is a 15.6-kb transposon found in Tn6103 of Clostridium difficile strain R20291. It contained 21 ORFs, encoding a recombinase, a putative transcriptional regulator (ORF 1747), a two-component regulatory system (ORFs 1748 and 1749), an ABC transporter (ORFs 1750, 1751 and 1752), three sigma factor-like proteins (ORFs 1754, 1755 and 1756), a putative toxin-antitoxin system (ORFs 1759 and 1760) and a phage-associated protein (ORF 1762).
References

Brouwer MSM, Warburton PJ, Roberts AP, Mullany P, Allan E. Genetic Organisation, Mobility and Predicted Functions of Genes on Integrated, Mobile Genetic Elements in Sequenced Strains of Clostridium difficile . Highlander SK, ed. PLoS ONE. 2011;6(8):e23014. DOI: 10.1371/journal.pone.0023014.

Accession number
Contact
m.brouwer@ucl.ac.uk
Tn6105
Mr Michael Brouwer
UCL Eastman Dental Institute
Characteristics
Tn6105 is a 15.8-kb transposon found in Tn6103 of Clostridium difficile strain R20291. It contained 11 ORFs, encoding two putative large serine recombinases (ORFs 1771-1772), TnpV (ORF 1765), a mobilisation protein (ORF 1768), a predicted sigma factor (ORF 1773) and a predicted orphan response regulator (ORF 1775).
References

Brouwer MSM, Warburton PJ, Roberts AP, Mullany P, Allan E. Genetic Organisation, Mobility and Predicted Functions of Genes on Integrated, Mobile Genetic Elements in Sequenced Strains of Clostridium difficile . Highlander SK, ed. PLoS ONE. 2011;6(8):e23014. DOI: 10.1371/journal.pone.0023014.

Accession number
Contact
m.brouwer@ucl.ac.uk
Tn6106
Mr Michael Brouwer
UCL Eastman Dental Institute
Characteristics
Tn6106 is an 11.3-kb transposon found in Tn6103 of Clostridium difficile strain R20291. It contained 11 ORFs, encoding a large serine recombinase gene (ORF 1788), a TnpV homologue (ORF 1777), a predicted mobilisation protein (ORF 1784) and a predicted transcriptional regulator (ORF 1778).
References

Brouwer MSM, Warburton PJ, Roberts AP, Mullany P, Allan E. Genetic Organisation, Mobility and Predicted Functions of Genes on Integrated, Mobile Genetic Elements in Sequenced Strains of Clostridium difficile . Highlander SK, ed. PLoS ONE. 2011;6(8):e23014. DOI: 10.1371/journal.pone.0023014.

Accession number
Contact
m.brouwer@ucl.ac.uk

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