The Transposon Registry

Displaying 121 - 140 of 2083
Tn2350
  • Antibiotic Resistance
  • Kanamycin
Characteristics
Tn2350 is a 10.4 kb transposon which confers resistance to kanamycin. It is flanked by two directly repeated copies of IS1 element.
References

Clerget, M., Chandler, M., & Caro, L. (1980). Isolation of an IS1 flanked kanamycin resistance transposon from R1drd19. Molecular and General Genetics MGG, 180(1), 123-127. DOI: 10.1007/BF00267360

Tn2353
  • Antibiotic Resistance
  • Spectinomycin
  • Sulphonamide
  • Heavy Metal Resistance
  • Mercury Resistance
Characteristics
Tn2353 is a 13.0 kb transposon which carries genes that confer resistance to mercury, spectinomycin and sulphonamide.
References

Dobritsa, A. P. (1984). IS8-and Tn2353-mediated cointegration of the plasmids R15 and RP4:: Tn1. Molecular and General Genetics MGG, 194(1), 206-210. DOI: 10.1007/BF00383518

 

Tn2354
Characteristics
Tn2354 is a 7.8 kb transposon detected on plasmid R15. It was found to be located very close to Tn2353 within the same plasmid.
References

Dobritsa, A. P., Mikhailova, T. G., & Dubovaya, V. I. (1985). Physical and genetic structure of the IncN plasmid R15. Plasmid, 14(2), 99-105. DOI: 10.1016/0147-619X(85)90069-1

Tn2401
  • Antibiotic Resistance
  • Gentamicin
  • Kanamycin
  • Neomycin
Characteristics
Tn2401 is a 7.1 kb transposon that encodes an aminoglycoside 3′-phosphotransferase and an aminoglycoside 6′-N-acetyltransferase. It was detected in a clinical isolate of Pseudomonas aeruginosa. Tn2401 confers resistance to gentamicin, tobramycin, sisomicin, netilmycin, and dibekacin via aacA and to paromomycin, lividomycin, kanamycin, and neomycin via aph-(3’).
References

Schmidt, F., Kratz, J., & Wiedemann, B. (1983). Identification of Tn2401, a transposon encoding multiresistance to aminoglycosides.Microbiology, 129(5), 1527-1536. doi: 10.1099/00221287-129-5-1527

Tn2410
  • Antibiotic Resistance
  • Ampicillin
  • Sulphonamide
  • Heavy Metal Resistance
  • Mercury Resistance
Characteristics
Tn2410 is a 18.5 kb transposon which mediates resistance to ampicillin, sulfonamides, and mercury. It was detected in R-factor R1767 of Salmonella typhimurium.
References

Kratz, J., Schmidt, F., & Wiedemann, B. (1983). Characterization of Tn2411 and Tn2410, two transposons derived from R-plasmid R1767 and related to Tn2603 and Tn21. Journal of Bacteriology, 155(3), 1333-1342. PMCID: PMC217832

Tn2411
  • Antibiotic Resistance
  • Streptomycin
  • Sulphonamide
  • Heavy Metal Resistance
  • Mercury Resistance
Characteristics
Tn2411 is a 18.0 kb transposon which mediates resistance to streptomycin, sulfonamides, and mercury. Tn2411 was isolated from Salmonella typhimurium R-factor R1767.
References

Kratz, J., Schmidt, F., & Wiedemann, B. (1983). Characterization of Tn2411 and Tn2410, two transposons derived from R-plasmid R1767 and related to Tn2603 and Tn21. Journal of Bacteriology, 155(3), 1333-1342. PMCID: PMC217832

Tn2424
  • Antibiotic Resistance
  • Amikacin
  • Chloramphenicol
  • Spectinomycin
  • Streptomycin
  • Sulphonamide
  • Heavy Metal Resistance
  • Mercury Resistance
Characteristics
Tn2424 is a 25 kb transposon isolated from IncFII plasmid NR79. It mediates resistance to sulfonamides, streptomycin-spectinomycin, mercuric chloride, chloramphenicol, and amikacin. Resistance to amikacin is mediated by a 6'-N-acetyltransferase.
References

Meyer, J. F., Nies, B. A., & Wiedemann, B. E. R. N. D. (1983). Amikacin resistance mediated by multiresistance transposon Tn2424. Journal of Bacteriology, 155(2), 755-760. PMCID: PMC217747

Accession number
Tn2425
  • Antibiotic Resistance
  • Spectinomycin
  • Streptothricin
  • Sulphonamide
  • Heavy Metal Resistance
  • Mercury Resistance
Characteristics
Tn2425 belongs to Tn21-family transposon which was formed by transposition of IS161 into Tn21. It mediates resistance to streptomycin-spectinomycin, sulphonamide and mercury.
References

Meyer, J.F., Nies, B. A., Kratz, J., & Wiedemann, B. (1985). Evolution of Tn21-related transposons: isolation of Tn2425, which harbours IS161. Microbiology, 131(5), 1123-1130. DOI: 10.1099/00221287-131-5-1123

Tn2426
  • Antibiotic Resistance
  • Amikacin
  • Chloramphenicol
  • Gentamicin
  • Spectinomycin
  • Streptomycin
  • Sulphonamide
  • Heavy Metal Resistance
  • Mercury Resistance
Characteristics
Tn2426 is a typical member of the Tn21 family of class II transposons. It carries resistance genes for sulphonamide (sul1), streptomycin-spectinomycin (aadA), gentamicin (aadB), amikacin (aacA), chloramphenicol (cat) and mercury (mer).
References

Zühlsdorf, M. T., & Wiedemann, B. (1993). Functional and physiological characterization of the Tn21 cassette for resistance genes in Tn2426. Microbiology, 139(5), 995-1002. DOI: 10.1099/00221287-139-5-995

Wiedemann, B., Meyer, J. F., & Zühlsdorf, M. T. (1986). Insertions of resistance genes into Tn 21-like transposons. Journal of Antimicrobial Chemotherapy, 18(Supplement_C), 85-92. DOI:https://doi.org/10.1093/jac/18.Supplement_C.85

Accession number
Tn2440
  • Antibiotic Resistance
  • Tetracycline
Characteristics
Tn2440 is a 4.0 kb composite transposon which mediates resistance to tetracycline. The Tn2440 is flanked by direct repeats of the insertion sequence IS160.
References

Nies, B. A., Meyer, J. F., & Wiedemann, B. (1985). Tn2440, a composite tetracycline resistance transposon with direct repeated copies of IS160 at its flanks. Microbiology, 131(9), 2123-2127. DOI: 10.1099/00221287-131-9-2443

Tn2501
Characteristics
Tn2501 is a 6.3-kb transposon that was originally found as part of Tn951. It contains transposase (tnpA) and resolvase (tnpR) genes.
References

Michiels, T., Cornelis, G., Ellis, K., & Grinsted, J. (1987). Tn2501, a component of the lactose transposon Tn951, is an example of a new category of class II transposable elements. Journal of Bacteriology, 169(2), 624–631. DOI: 10.1128/jb.169.2.624-631.1987

Accession number
Tn2502
  • Heavy Metal Resistance
  • Arsenate resistance
Characteristics
Tn2502 is a 4.6-kb transposon, found in Yersinia enterocolitica on plasmid pYVe439-80. It contains defective transposase and genes conferring arsenite and arsenate resistance (arsB, arsC, arsR, arsH).
References

Neyt, C., Iriarte, M., Thi, V. H., & Cornelis, G. R. (1997). Virulence and arsenic resistance in Yersiniae. Journal of Bacteriology, 179(3), 612–619. DOI: 10.1128/jb.179.3.612-619.1997

Accession number
Tn2503
  • Heavy Metal Resistance
  • Arsenate resistance
Characteristics
Tn2503 is a 6.8-kb transposon, found in plasmids from Yersinia pestis strain Java 9. It is related to Tn2502 without the deletions in transposase tnpA gene. It contains arsHRBC four-gene system that mediates arsenic resistance.
References

Eppinger, M., Radnedge, L., Andersen, G., Vietri, N., Severson, G., Mou, S., … Worsham, P. L. (2012). Novel Plasmids and Resistance Phenotypes in Yersinia pestis: Unique Plasmid Inventory of Strain Java 9 Mediates High Levels of Arsenic Resistance. PLoS ONE, 7(3), e32911. DOI: 10.1371/journal.pone.0032911

Accession number
Tn2505
Characteristics
Tn2505 is a minor 8.2-kb transposon on plasmid pMBLG2. It was constructed based on Tn951/Tn2501 by replacing the 10.5 kb BamHI fragment with a kanamycin resistance (neo) gene of Tn5.
References

Michiels, T. and G. Cornelis (1986). Tn951 derivatives designed for high-frequency plasmid-specific transposition and deletion mutagenesis. Gene 43(3): 175-181. DOI: 10.1016/0378-1119(86)90205-2

Tn2506
  • Antibiotic Resistance
  • Chloramphenicol
Characteristics
Tn2506 is a 7.3-kb minor transposon on plasmid pMBLG3, which was constructed by replacing neo gene with the chloramphenicol acetyltransferase (cat) gene on pMBLG2.
References

Michiels, T. and G. Cornelis (1986). Tn951 derivatives designed for high-frequency plasmid-specific transposition and deletion mutagenesis. Gene 43(3): 175-181. DOI: 10.1016/0378-1119(86)90205-2

Tn2507
  • Antibiotic Resistance
  • Chloramphenicol
  • Kanamycin
Characteristics
Tn2507 is a 9.1-kb transposon, constructed by cloning the chloramphenicol acetyltransferase (cat) gene into BamHI site on Tn2505 (containing e kanamycin resistance (neo) gene).
References

Mulder, B., Michiels, T., Simonet, M., Sory, M. P., & Cornelis, G. (1989). Identification of additional virulence determinants on the pYV plasmid of Yersinia enterocolitica W227. Infection and Immunity, 57(8), 2534–2541. PMID: 2545628 

Tn2515
  • Antibiotic Resistance
  • Kanamycin
  • Tetracycline
Characteristics
Tn2515 is a major transposon on plasmid pMBLG2, which contains Tn2505 (kanamycin resistance gene) with the addition of transposase tnpA gene (from Tn3) and tetracycline resistance gene.
References

Michiels, T. and G. Cornelis (1986). Tn951 derivatives designed for high-frequency plasmid-specific transposition and deletion mutagenesis. Gene 43(3): 175-181. DOI: 10.1016/0378-1119(86)90205-2

Tn2516
  • Antibiotic Resistance
  • Chloramphenicol
  • Tetracycline
Characteristics
Tn2516 is a major transposon on plasmid pMBLG3, which contains Tn2506 (chloramphenicol resistance gene) with the addition of transposase tnpA gene (from Tn3) and tetracycline resistance gene.
References

Michiels, T. and G. Cornelis (1986). Tn951 derivatives designed for high-frequency plasmid-specific transposition and deletion mutagenesis. Gene 43(3): 175-181. DOI: 10.1016/0378-1119(86)90205-2

Tn2521
  • Antibiotic Resistance
  • Spectinomycin
  • Streptomycin
  • Sulphonamide
  • Carbenicillin
Characteristics
Tn2521 is a 7-kb class 1 integron In33, isolated from several different clinical P. aeruginosa strains. It contains a backbone structure identical to that of In4 from Tn1696. Two gene cassettes are located on this transposon, blaP1 and aadA1.
References

Partridge, S. R., Brown, H. J., & Hall, R. M. (2002). Characterization and Movement of the Class 1 Integron Known as Tn2521 and Tn1405. Antimicrobial Agents and Chemotherapy, 46(5), 1288–1294. DOI: 10.1128/AAC.46.5.1288-1294.2002

Accession number
Tn2523
  • Antibiotic Resistance
  • Kanamycin
Characteristics
Tn2523 is a derivative of transposon Tn5, constructed by cloning DNA primase gene of the promiscuous IncP-1 conjugative plasmid RP1 into Tn5 (containing kanamycin resistance gene).
References

Krishnapillai, V., et al. (1986). Molecular cloning into Tn5 and integration in the Pseudomonas aeruginosa chromosome: a tool for heterologous gene expression. J Gen Microbiol 132(3): 707-715. DOI: 10.1099/00221287-132-3-707

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