Tn registry

Displaying 901 - 911 of 911
Tn6644
Dr Marco Maria D'Andrea
University of Siena
Characteristics
Tn6644 is a composite transposon composed by two ISEnfa5 arranged in the same orientation flanking the cfr multiresistance gene. This structure have been found in several microbial species, either located in the chromosome or on plasmids. Its mobilization by transposition could be suggested observing the different target site duplications of 3 bp found in distinct genetic environments. A part of Tn6644 comprising a copy of ISEnfa5, the cfr gene and the sequences between cfr and two ISEnfa5 elements, is able to looping-out giving circular intermediates. The passenger gene cfr is a rRNA methyltransferase that acts on a conserved 23S rRNA residue, conferring resistance to an array of ribosomal antibiotics, including phenicols, lincosamides, pleuromutilins, streptogramins A, 16-member ring macrolides and oxazolidinones.
References

D'Andrea, M.M. et al. 2018. Direct submission.
Wang, Y., et al. 2013. Antimicrob. Agents Chemother. 57 (8), 4061-4063.

Accession number
Contact
Tn6645
Miss Felise Adams
Tn6646
kaixin zhou
Tn6647
Ricardo León-Sampedro
Tn6648
Ricardo León-Sampedro
Tn6649
Ms Agila kumari Pragasam
Tn6650
Ms Agila kumari Pragasam
Tn1207.1
  • Antibiotic Resistance
  • Erythromycin
Characteristics
Tn1207.1 is a 7244 bp transposon, isolated from a clinical isolate of Streptococcus pneumoniae. It contains 8 open reading frames, which two of them were macrolide resistance genes, mef(A) and msr(SA). orf6, orf7, and orf8 are homologous to 3 ORFs of conjugative transposon Tn5252.
References

Santagati M, et al. (2000). Characterization of a Genetic Element Carrying the Macrolide Efflux Gene mef(A) in Streptococcus pneumoniaeAntimicrobial Agents and Chemotherapy44(9), 2585–2587. doi: 10.1128/AAC.44.9.2585-2587.2000

Accession number
Tn2555.1
Characteristics
Tn2555.1 is a 14.2-kb transposon containing three IS26 elements. Two of the IS26 elements are flanking genes for sucrose metabolism (scr genes), which are including scrK (encoding ATP-dependent fructokinase), scrYAB (encoding enzymes for phosphotransferase system (PTS)-dependent sucrose fermentation pathway) and scrR (repressor) genes.
References

Doroshenko, V. G. and V. A. Livshits (2004). Structure and mode of transposition of Tn2555 carrying sucrose utilization genes. FEMS Microbiol Lett 233(2): 353-359. DOI: 10.1016/j.femsle.2004.03.016

Accession number
Tn2555.3
Characteristics
Tn2555.3 is a variant of Tn2555 with the size of 14.2-kb. It contains genes for sucrose metabolism flanked by invert repeated IS26 elements same as Tn2555.1, but the genes are oriented in opposite direction.
References

Doroshenko, V. G. and V. A. Livshits (2004). Structure and mode of transposition of Tn2555 carrying sucrose utilization genes. FEMS Microbiol Lett 233(2): 353-359. DOI: 10.1016/j.femsle.2004.03.016

Accession number
Tn4453a
  • Antibiotic Resistance
  • Chloramphenicol
Characteristics
Tn4453a is a chloramphenicol resistance transposon similar to Tn4451. The chloramphenicol resistance is mediated by catD gene. It was detected in Clostridium difficile. The Tn4453a was found to be co-existed with another transposon, Tn4453b in C. difficile.
References

Lyras, D., Storie, C., Huggins, A. S., Crellin, P. K., Bannam, T. L., & Rood, J. I. (1998). Chloramphenicol resistance in Clostridium difficile is encoded on Tn4453 transposons that are closely related to Tn4451 from Clostridium perfringens. Antimicrobial Agents and Chemotherapy42(7), 1563-1567. DOI: PMCID: PMC105645

Accession number

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