The Transposon Registry

Displaying 2021 - 2040 of 2172

Tn7712

Dr Yuxia Zhong

Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China

Antibiotic Resistance
Amoxicillin
Ampicillin

Characteristics

Tn7712 is a 15017bp transposon, flanked by inverted repeats of insertion sequence ISkpn19. This transposon confers beta-lactam resistance via blakpc-2. The blaKPC-2 gene was located in an ISKpn19-orf1-orf2-Tn3-ISKpn27-blaKPC-2-ISKpn6-orf2-orf1-ISKpn19 structure.

Accession number

Contact

yuxia0301@163.com

Tn7713

Janko Sattler

Contact

janko.sattler@uk-koeln.de

Tn7714

Ivan Munoz Gutierrez

University of California, Irvine

Characteristics

Tn7714 is a 22.6 Kb transposon that is a Tn21 and Tn1721 hybrid. Tn7714 contains the resolution site, tnpR, tpnA, tetR, tetA (tetracycline resistance), and delta-tnpA from Tn1721 (99% identical). The mercury resistance operon (merR, merT, merP, merC, merA, merD, and merE), urf2, intI1, and tnpM are from Tn21 (99-100% identical). The intI1 integron carries the trimethoprim resistance gene dfrA5. An IS26 composite transposon between the mercury resistance operon and the intI1 integron carries resistance genes for aminoglycosides (strB, strA) and sulfamethoxazole (sul2). Tn7714 was found in an IncF plasmid (NZ_CP107285.1) from an Escherichia coli (GCA_025808215.1) isolated from a Baton Rouge, Louisiana lake. During a conjugation experiment, Tn7714 moved from the IncF plasmid into a cryptic IncX plasmid, creating a new multidrug resistance IncX plasmid (NZ_CP110861.1).

References

Muñoz-Gutiérrez I, Cantu L, Shanahan J, Girguis M, de la Cruz M, Mota-Bravo L. 2024. Cryptic environmental conjugative plasmid recruits a novel hybrid transposon resulting in a new plasmid with higher dispersion potential. mSphere 0:e00252-24.
https://doi.org/10.1128/msphere.00252-24

Accession number

Contact

ivan.munoz.gutierrez@gmail.com

Tn7715

yang liuyang

Contact

604025735@qq.com

Tn7716

yang liuyang

Contact

604025735@qq.com

Tn7717