The Transposon Registry

Tn7359 is an ISKpn14 composite transposon, detected on pBACpAK entrapment vector in an E. coli transconjugant that acquired a plasmid from Klebsiella pneumoniae strain 50825040. It contains a Tn21-like structure (merCAD mercury resistance genes, urf2, and tniA genes), an IS26-based pseudo-compound transposon (PCT)-like structure, a conjugative module, and a plasmid stability/replication module. The IS26 PCT-like structure contained multiple β-lactamase genes (blaTEM-1, blaOXA-9, blaCTX-M-15, and blaNDM-1), aminoglycoside resistance genes (ant1, aacA4, and aphA), the bleomycin resistance gene, and the qnrS1 quinolone resistance gene. It also carried several IS elements, including ISEcp1, ISEc36, ISSpu2, ISKpn19, ISKpn8, and ISKpn25.