Tn registry

Displaying 61 - 80 of 623
Tn1013
Characteristics
Tn1013 is a 8.2 kb transposon related to Tn3-family transposon found to be located on plasmid pBS228 of Pseudomonas aeruginosa.
References

Haines, A. S., Jones, K., Batt, S. M., Kosheleva, I. A., & Thomas, C. M. (2007). Sequence of plasmid pBS228 and reconstruction of the IncP-1α phylogeny. Plasmid58(1), 76-83. DOI: 10.1016/j.plasmid.2007.01.001

Accession number
Tn1021
  • Antibiotic Resistance
  • Tetracycline
Characteristics
Tn1021 is a 6 kb transposon carrying a tetracycline resistance determinant. Unlike other IS-associated transposon, the Tn1021 is not flanked by two copies of IS102, but contains only a single copy of IS102 at one end.
References

Machida, Y., Machida, C., & Ohtsubo, E. (1982). A novel type of transposon generated by insertion element IS102 present in a pSC101 derivative. Cell,30(1), 29-36. DOI: http://dx.doi.org/10.1016/0092-8674(82)90008-3

Tn1022
  • Antibiotic Resistance
  • Tetracycline
Characteristics
Tn1022 is a 10 kb transposon carrying a tetracycline resistant determinant. Similar to Tn1021 it contains a single copy of IS102 at one end only.
References

Machida, Y., Machida, C., & Ohtsubo, E. (1982). A novel type of transposon generated by insertion element IS102 present in a pSC101 derivative. Cell,30(1), 29-36. DOI: 10.1016/0092-8674(82)90008-3

Tn1116
  • Antibiotic Resistance
  • Erythromycin
Characteristics
Tn1116 is a Tn916 family transposon resulting from the insertion of erm(B)-IS1216 DNA into the tet(M) gene of a defective Tn5397.
References

Brenciani A, et al. (2007). Genetic Elements Carrying erm(B) in Streptococcus pyogenes and Association with tet(M) Tetracycline Resistance Gene . Antimicrobial Agents and Chemotherapy51(4), 1209–1216. doi: 10.1128/AAC.01484-06

Accession number
Tn1213
  • Antibiotic Resistance
  • ceftazidime
Characteristics
Tn1213 is a 4192 bp composite transposon. It contains blaPER-1 and truncated glutathione-S-transferases (gst) genes, which are flanked by ISPa12 and ISPa13.
References

Poirel, L., Cabanne, L., Vahaboglu, H., & Nordmann, P. (2005). Genetic Environment and Expression of the Extended-Spectrum β-Lactamase blaPER-1Gene in Gram-Negative Bacteria. Antimicrobial Agents and Chemotherapy49(5), 1708–1713. doi: 10.1128/AAC.49.5.1708-1713.2005

Accession number
Tn1331
  • Antibiotic Resistance
  • Ampicillin
  • Kanamycin
  • Streptomycin
Characteristics
Tn1331 consists of a Tn3 transposon (carrying blaTEM-1 gene) and two gene cassettes carrying three antibiotic-resistance genes, which are aac(6′)-Ib, ant(3″)-Ia and blaOXA-9 genes, conferring resistance to kanamycin, streptomycin and beta-lactams, respectively.
References

Alavi MR, et al. (2011). An Enterobacter plasmid as a new genetic background for the transposon Tn1331Infection and Drug Resistance4, 209–213. doi: 10.2147/IDR.S25408

 

 

 

Accession number
Tn1332
  • Antibiotic Resistance
  • Ampicillin
  • Carbapenem
  • Kanamycin
  • Streptomycin
Characteristics
Tn1332 is an 11 kb transposon which is closely related to Tn1331. It carries the metallo-β-lactamase gene blaVIM-2, in addition to those found in Tn1331, and two insertion sequences, ISPpu17 and ISPpu18.
References

Poirel L, et al. (2006). Class II Transposon-Borne Structure Harboring Metallo-β-Lactamase Gene blaVIM-2 in Pseudomonas putidaAntimicrobial Agents and Chemotherapy50(8), 2889–2891. doi: 10.1128/AAC.00398-06

Accession number
Tn1401
  • Antibiotic Resistance
  • Ampicillin
  • Spectinomycin
  • Streptomycin
  • Sulphonamide
  • Heavy Metal Resistance
  • Mercury Resistance
Characteristics
Tn1401 is a 15.9 kb transposon, which is related to Tn21 and found on plasmid pMG217 from Salmonella typhimurium. It contains mer, sul, aadA and bla (PSE- 1) genes, conferring resistance to mercury, sulphonamide, streptomycin and ampicillin, respectively.
References

Levesque, RC. and G. A. Jacoby (1988). Molecular structure and interrelationships of multiresistance beta-lactamase transposons. Plasmid 19(1): 21-29. doi: 10.1016/0147-619X(88)90059-5

Medeiros AA, et al. (1982). Spread of a “Pseudomonas-specific” beta-lactamase to plasmids of enterobacteria. Journal of Bacteriology149(2), 700–707. PMID: 6276367

Tn1402
  • Antibiotic Resistance
  • Ampicillin
  • Spectinomycin
  • Streptomycin
  • Sulphonamide
  • Heavy Metal Resistance
  • Mercury Resistance
Characteristics
Tn1402 is related to Tn21, found on plasmid pMG209. It is similar to Tn1401, which contains mer, sul, aadA and bla (PSE- 1) genes, conferring resistance to mercury, sulphonamide, streptomycin and ampicillin, respectively.
References

Medeiros AA, et al. (1982). Spread of a “Pseudomonas-specific” beta-lactamase to plasmids of enterobacteria. Journal of Bacteriology149(2), 700–707. PMID: 6276367

Tn1403
  • Antibiotic Resistance
  • Ampicillin
  • Chloramphenicol
  • Spectinomycin
  • Streptomycin
Characteristics
Tn1403 is a 19.6 kb transposon from a clinical Pseudomonas strain. It is composed of the transposon backbone (tnpA and tnpR), a class I integron In28 (6.27 kb), and a Tn5393c (Tn5393 without insertion sequence). Three resistance genes (blaP1-cmlA1-aadA1) are located as gene cassettes within In28. Streptomycin resistance genes (strA and strB) are located in Tn5393c.
References

Stokes HW, et al. (2007). Tn1403, a Multiple-Antibiotic Resistance Transposon Made Up of Three Distinct Transposons. Antimicrobial Agents and Chemotherapy51(5), 1827–1829. doi: 10.1128/AAC.01279-06

Accession number
Tn1404
  • Antibiotic Resistance
  • Streptomycin
  • Sulphonamide
  • Tetracycline
Characteristics
Tn1404 is isolated from Pseudomonas sp. isolate R9 with a size of 19-kb. It composes of the transposon backbone (tnpA and tnpR), an integron, and a IS26-composite transposon. Its integron contains a single aadA2 cassette and sul1 gene, conferring streptomycin and sulfonamide resistance. Tetracycline resistance genes (tetC and tetR) are located in the composite transposon.
References

Schnabel, E. L., & Jones, A. L. (1999). Distribution of Tetracycline Resistance Genes and Transposons among Phylloplane Bacteria in Michigan Apple Orchards. Applied and Environmental Microbiology65(11), 4898–4907. PMID: 10543801

Accession number
Tn1405
  • Antibiotic Resistance
  • Ampicillin
  • Spectinomycin
  • Streptomycin
  • Sulphonamide
Characteristics
Tn1405 is a 8 kb transposon, isolated from the chromosome of Pseudomonas aeruginosa Dalgleish. It carries sul1, aadA and blaP1 genes.
References

Partridge SR, et al. (2002). Characterization and Movement of the Class 1 Integron Known as Tn2521 and Tn1405Antimicrobial Agents and Chemotherapy46(5), 1288–1294. doi: 10.1128/AAC.46.5.1288-1294.2002

Tn1523
  • Antibiotic Resistance
  • Tetracycline
Characteristics
Tn1523 is a 10.8 kb transposon carrying a tetracycline resistance determinant. Tn1523 is very similar to Tn1721 and Tn1771.
References

Briaux-Gerbaud, S., Gerbaud, G., & Jaffé-Brachet, A. (1981). Transposition of a tetracycline-resistance determinant (Tn1523) and cointegration events mediated by the pIP231 plasmid in Escherichia coli. Gene15(2), 139-149. PMID:6271638

Tn1525
  • Antibiotic Resistance
  • Kanamycin
Characteristics
Tn1525 is a 4.44 kb transposon that confers resistance to kanamycin via an aminoglycoside phosphotransferase (aph) gene. It was originally detected on plasmid pIP112 (IncI1) of Salmonella panama.
References

Labigne-Roussel, A., Briaux-Gerbaud, S., & Courvalin, P. (1983). Tn1525, a kanamycin R determinant flanked by two direct copies of IS15. Molecular and General Genetics MGG189(1), 90-101. PMID: 6304464

Tn1527
  • Antibiotic Resistance
  • Spectinomycin
  • Streptomycin
  • Trimethoprim
Characteristics
Tn1527 is a 14 kb transposon closely related to Tn7. It carries a dihydrofolate reductase gene that confers resistance to trimethoprim and a adenyltransferase gene responsible for streptomycin-spectinomycin resistance.
References

Goldstein, F., Gerbaud, G., & Courvalin, P. (1986). Transposable resistance to trimethoprim and 0/129 in Vibrio cholerae. Journal of Antimicrobial Chemotherapy17(5), 559-569.  DOI: 10.1093/jac/17.5.559

Tn1528
  • Antibiotic Resistance
  • Amikacin
Characteristics
Tn1528 is 5.2 kb transposon carrying an aph(3')-VIa gene that confers resistance to amikacin.
References

Lambert, T., Gerbaud, G., & Courvalin, P. (1994). Characterization of transposon Tn1528, which confers amikacin resistance by synthesis of aminoglycoside 3'-O-phosphotransferase type VI. Antimicrobial agents and chemotherapy38(4), 702-706. PMCID: PMC284528

Tn1545
  • Antibiotic Resistance
  • Erythromycin
  • Kanamycin
  • Lincomycin
  • Streptogramin B
  • Tetracycline
Characteristics
Tn1545 is a 25.3 kb conjugative transposon related to Tn916 and was originally detected in the chromosome of Streptococcus pneumoniae BM4200, The Tn1545 encodes resistance to kanamycin via aphA-3, to macrolide-lincosamide-streptogramin B-type (MLS) antibiotics via ermAM, and to tetracycline via tet(M). The Tn1545 and Tn916 together comprise a large family of related conjugative transposons known as the Tn916/Tn1545 family.
References

Courvalin, P., & Carlier, C. (1986). Transposable multiple antibiotic resistance in Streptococcus pneumoniae. Molecular and General Genetics MGG205(2), 291-297. DOI: 10.1007/BF00430441

Courvalin, P., & Carlier, C. (1987). Tn1545: a conjugative shuttle transposon.Molecular and General Genetics MGG206(2), 259-264. DOI: 10.1007/BF00333582

Tn1546
  • Antibiotic Resistance
  • Teicoplanin
  • Vancomycin
Characteristics
Tn1546 is a 10.8 kb transposon related to Tn3 and was originally detected on pIP816 of Enterococcus faecium BM4147. It carries a vanA operon responsible for resistance to glycopeptides. Several genetic variations, including the presence of insertion sequences or deletions in nonessential genes and/or intergenic regions, have been reported in Tn1546.
References

Arthur, M. I. C. H. E. L., Molinas, C., Depardieu, F., & Courvalin, P. (1993). Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. Journal of Bacteriology175(1), 117-127. DOI10.1128/jb.175.1.117-127.1993

Accession number
Tn1547
  • Antibiotic Resistance
  • Vancomycin
Characteristics
Tn1547 is a 64 kb composite transposon harbouring a vanB gene cluster which was originally identified on the chromosome of Enterococcus faecalis BM4281. Tn1547 is demarked by two distantly related insertion sequences (IS), designated as IS256 (1324 bp) and IS16 (1466 bp). This transposon was shown to translocate from the chromosome of Enterococcus faecalis BM4281 to hemolysin plasmid, pIP964.
References

Quintiliani, R., & Courvalin, P. (1996). Characterization of Tn1547, a composite transposon flanked by the IS16 and IS256-like elements, that confers vancomycin resistance in Enterococcus faecalis BM4281. Gene,172(1), 1-8. DOI: 10.1016/0378-1119(96)00110-2

Tn1548
  • Antibiotic Resistance
  • Fortimicin
  • Spectinomycin
  • Streptomycin
  • Sulphonamide
  • Trimethoprim
Characteristics
Tn1548 is a 16.6 kb composite transposon which confers resistance fortimicin, streptomycin-spectinomycin, sulfonamides, and trimethoprim via armA, ant3"9, sul1, and dfrXII genes. It was found to be located on plasmid, pIP1204. The Tn1548 is flanked by two copies of IS6 in direct orientation.
References

Galimand, M., Sabtcheva, S., Courvalin, P., & Lambert, T. (2005). Worldwide disseminated armA aminoglycoside resistance methylase gene is borne by composite transposon Tn1548. Antimicrobial Agents and Chemotherapy,49(7), 2949-2953. DOI: 10.1128/AAC.49.7.2949-2953.2005

 

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